8th International mRNA Health Conference

PROGRAM of the 8th International mRNA Health Conference​

(All times shown as Eastern Standard Time, EST)

DAY 1: Monday, November 9th 2020

08:00 – 08:15Welcome & LogisticsStephane Bancel and Melissa Moore
08:15 – 09:45Session I: mRNA Biology and TranslationChair: Melissa Moore 
08:15 – 08:40Single-cell transcriptome imaging and cell atlas of complex tissuesXiaowei Zhuang (HHMI/Harvard Chemistry)
08:40 – 09:05Colliding ribosomes function as a gauge for activation of cellular stress responsesRachel Green (HHMI/Johns Hopkins Medical School)
09:05 – 09:30Development of RNA structures for cancer immunotherapy

Kyuri Lee (Gyeongsang National University)

09:30 – 09:45Decoding mRNA translatability and stability from the 5’UTRShu-Bing Qian (Cornell University)
09:45 – 10:00Break 
10:00 – 10:05Keynote IntroductionStephane Bancel
10:05 – 10:30Keynote Speaker
Please note: Taped talk – No Q&A
Anthony Fauci (NIAID/NIH) 
10:30 – 11:00Break 
11:00 – 12:55Session II: DeliveryChair: Dan Siegwart
11:00 – 11:20mRNA DeliveryDan Anderson (MIT)
11:20 – 11:40Biomaterials strategies to enhance and prolong the effects of therapeutic mRNAWilliam L. Murphy (U.Wisconsin-Madison)
11:40 – 12:00Supramolecular assemblies for enhanced mRNA deliveryHoracio Cabral (U. Tokyo)
12:00 – 12:20Boosting intracellular delivery of messenger RNAGaurav Sahay (OHSU)
12:20 – 12:40Advancing pulmonary delivery of mRNA therapeutics for the treatment of genetic diseasesJohn Androsavich (Translate Bio)
12:40 – 12:55COATSOME SS-Lipids as novel, biodegradable, ionizable Lipids for mRNA Therapeutics and VaccinesSyed Reza (NOF America)
12:55 – 13:10Break 
13:10 – 14:40Session III: Prophylactic and Therapeutic VaccinesChair: Norbert Pardi
13:10 – 13:30Development of broadly protective influenza virus vaccines using nucleoside-modified mRNANorbert Pardi (UPenn)
13:30 – 13:50A mRNA-LNP vaccine against Dengue Virus elicits robust, serotype-1 specific immunityJustin M Richner (University of Illinois)
13:50 – 14:10Intranasal mRNA Vaccines:  COVID and far beyondWim Tiest (Etherna)
14:10 – 14:25Therapeutic vaccination of cancer patients with WT1 mRNA-electroporated dendritic cells:  Using mRNA as an active substance in the clinic since 2005Zwi Berneman (Antwerp Univ Hospital)
14:25 – 14:40Immunodominant Malaria Antigen, pfcsp Induces Functional, Protective Immune Responses in Mice using mRNA PlatformKatherine Mallory (Walter Reed Army Institute of Research)
14:40 – 14:55Developing an mRNA Vaccine Platform Across Multiple Infectious Disease TargetsDanilo Casimiro (Sanofi)
Frank DeRosa (TranslateBio)
14:55 – 15:10Break 
15:10 – 16:30Session IV: Manufacturing, Analytics and CommercializationChair: Patrick Baumhof
15:10 – 15:30Meeting the quality and scale requirements for IVT enzymes in the production of therapeutic mRNAsJohn Pelletier (New England Biolabs)
15:30 – 15:50Strategic CDMO partnering for accelerated mRNA vaccine development: A COVID-19 case studyAnton McCaffrey (TriLink BioTechnologies)
15:50 – 16:10Characterizing the therapeutic application of mRNA-lipid nanoparticlesThomas Madden (Acuitas)
16:10 – 16:30Enabling mRNA Platform Commercialization and Setting Up for Future SuccessTadas Trunca (Thermo Fisher)

DAY 2: Tuesday, November 10th 2020

08:00 – 09:15Session V: Gene and Base Editing of/with mRNAChair: Melissa Moore
08:00 – 08:25Spatial and environmental tuning of genetic information within the cephalopod nervous system by RNA editingJoshua Rosenthal (MBL Woods Hole)
08:25 – 08:50Base Editing and Prime Editing: Chemistry on the Genome Editing Without Double-Strand BreaksDavid Liu (Harvard Chemistry)
08:50 – 09:15Selective ORgan Targeting (SORT): A strategy for effective tissue specific mRNA delivery and gene editingDan Siegwart (UTSW)
09:15 – 09:30Break 
09:30 – 11:05Session VI: TherapeuticsChair: Josh Frederick 
09:30 – 09:55mRNA-Based Approach For Treating Ischemic Heart DiseaseLior Zangi (Mt Sinai)
09:55 – 10:20Intratumoral interleukin-12 mRNA therapy promotes TH1 transformation of the tumor microenvironmentNadia Luheshi (AstraZeneca)
10:20 – 10:35Onco-selective Messenger RNAs For Cancer Cell-Specific Protein ExpressionYusuf Erkul (Kernal Biologics)
10:35 – 10:50In Vivo Bone Tissue Induction by Collagen-nanohydroxyapatite Matrix Loaded with BMP2/NS1 mRNAs LipopolyplexesChantal Pichon (CNRS Orléans)
10:50 – 11:05Intraventricular BDNF mRNA administration prevents ischemic neuronal death with the uptake predominantly by astrocytesYuta Fukushima (Tokyo Medical and Dental Univ)
11:05 – 11:30Break 
11:30 – 14:45Session VII: Pandemic Responses/COVID-19Chair: Norbert Pardi
11:30 – 11:50mRNA platform advances and COVID-19 candidate vaccinesNicholas Jackson (CEPI)
11:50 – 12:15The Moderna mRNA Vaccine Platform to Address SARS-CoV-2Jackie Miller (Moderna)
12:15 – 12:40BioNTech’s SARS-CoV-2 mRNA vaccinesUgur Sahin (BioNTech)
12:40 – 13:05Development of SARS-CoV-2 vaccine based on CureVac’s mRNA technologyLidia Oostvogels (CureVac)
13:05 – 13:15Break 
13:15 – 13:40Development of a self-amplifying RNA SARS-CoV-2 vaccine candidateRobin Shattock (Imperial College, London)
13:40 – 14:05LUNAR®-COV19: The Arcturus Therapeutics SARS-CoV-2 mRNA Vaccine CandidateSean Sullivan (Arcturus Therapeutics)
14:05 – 14:25The Innovative Medicines Initiative: Responding to COVID-19 through a public-private partnershipPierre Meulien (Innovative Medicines Initiative)
14:25 – 14:45Break 
14:45 – 16:15Session VIII: Regulatory Considerations
Chair: Charbel Haber
14:45 – 15:00The Regulatory Landscape for mRNA Vaccines:  A U.S. PerspectiveNorman W. Baylor (Biologics Consulting)
15:00 – 15:15Regulatory Considerations Specific to mRNA-based SARS-CoV-2 VaccinesMichael Pfleiderer (Biopharma Excellence)
15:15 – 16:15Round Table Discussion with Drs. Baylor and Pfleiderer, and Regulatory Heads Charbel Haber from Moderna, John Talian from CureVac and Andreas Kuhn from BioNTechNorman W. Baylor (Biologics Consulting), Michael Pfleiderer (Biopharma Excellence), John Talian (CureVac), Charbel Haber (Moderna), Andreas Kuhn (BionTech)
16:15 – 16:30Closing and passing of the batonOrganizing Committee
bannermrnaaa

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