Status of the 26th of October – Subject to change
Monday, October 30, 2023 in Berlin only
- 06:00 - 10:00 pm, CET
Get Together at the Mercure MOA Berlin
Conference Day 1: Tuesday, October 31, 2023 / 08:15 am - 06:30 pm, CET
Only for on site participants in Berlin:
- 05:00 - 6:30 pm, CET
Poster Session (Odd numbered) & Exhibition
- 06:30 - 10:30 pm, CET
Dinner
Opening:
Welcome & Logistics
- 08:15 - 08:30 am, CET
- Opening: Welcome & Logistics
- Alexander Zehnder - CureVac
Session 1:
An introduction to mRNA Medicines
- 08:30 - 10:00 am, CET
- Chair: Katalin Karikó
- This first session will consist of a series of teaching lectures to provide newcomers with the necessary background to understand current state-of-the-art and remaining challenges for making future mRNA medicines
- 08:30 am, CET
- Katalin Karikó - University of Pennsylvania / University of Szeged
- mRNA History
- 08:48 am, CET
- Eckhard Jankowsky - ModeRNA
- mRNA Biology & Engineering
- 09:06 am, CET
- Patrick Baumhof - CureVac
- Formulation & Delivery
- 09:24 am, CET
- Norbert Pardi - University of Pennsylvania
- mRNA Vaccine Mechanisms
- 09:42 am, CET
- Tatiana Novobrantseva - ModeRNA
- mRNA Therapeutics
Coffee Break
- 10:00 - 10:30 am, CET
Session 2:
Translation
- 10:30 am - 12:30 pm, CET
- Chair: Eckhard Jankowsky
- 10:30 am, CET
- Jeffrey Chao - Friedrich Miescher Institute
- Imaging the life and death of mRNAs in single cells
- 10:54 am, CET
- Liang Huang - Oregon State University and Coderna.ai
- Optimized mRNA Design Improves Stability and Immunogenicity
- 11:18 am, CET
- Zefeng Wang - CAS Shanghai
- Translation of circular RNAs- from regulatory mechanism to therapeutic applications
- 11:36 am, CET
- Alicia Bicknell - ModeRNA
- Attenuating ribosome load improves protein output from therapeutic mRNAs by limiting translation-dependent mRNA decay
- 11:54 am, CET
- Qianqian Ni - National University of Singapore
- Development of folding messenger RNA technology for enhanced protein production
- 12:12 pm, CET
- Guillermo Garcia Marquina - NewEnglandBiolabs
- Streamlined DNA template preparation and co-transcriptional 5’ capped RNA synthesis enabled by solid-phase catalysis
Lunch Break
- 12:30 – 02:00 pm, CET
- Talks during the lunch break:
- 12:30 - 12:45 pm, CET
- Shigetomo Tsujihata - FujiFilm
- Fujifilm's capabilities for LNP formulation, Process Development and manufacturing solutions
- 13:45 - 02:00 pm, CET
- Oladimeji Fashola - Quantoom Biosciences
- A new paradigm in mRNA bioprocessing: Rabies construct in an Ntensify™ Midi engineering run
Session 3:
Vaccines I
- 02:00 pm - 03:30 pm, CET
- Chair: Norbert Pardi
- 02:00 pm, CET
- Sumana Chandramouli - ModeRNA
- Harnessing the power of mRNA technology for prevention and treatment of infectious diseases
- 02:16 pm, CET
- Andreas Kuhn - BioNTech
- Analyzing mRNA identity, ratio, and integrity in RNA mixtures
- 02:32 pm, CET
- Régis Gervier - Sanofi
- Leverage leading edge mRNA platform to drive sustainable growth in Vaccines
- 02:48 pm, CET
- Satoshi Uchida - Tokyo Medical and Dental University
- Naked mRNA Jet Injection into the Skin Enables the Robust Vaccination against SARS-CoV-2 in Mice and Cynomolgus Monkeys
- 03:01 pm, CET
- Jack Yoon - Vernagen LLC
- Strong Immune Protection against Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) in Mice immunized with Novel SFTSV mRNA Vaccine
- 03:14 pm, CET
- Magnus Hoffmann - Caltech - VIRTUALLY
- EABR Nanoparticles as a Platform Technology for Hybrid mRNA Vaccine Development
Coffee Break
- 03:30 - 04:00 pm, CET
Session 4:
Flash Poster Talks / New Company Introductions
- 04:00 - 05:00 pm, CET
- Chair: Mustafa Diken
- Flash Poster Talks & New Company Introductions - 5 minutes for each talk
- Poster #27
- Samuele Stazzoni - Fondazione Toscana Life Sciences
- Poster #79
- Joe Newman - Omega Tx
- Poster #8
- Marie Berger - Myriade
- Poster #105
- Katherine Schultheis - ACM Biosciences
- Poster #43
- Eunbin Cho - Konkuk University, Seoul
- Poster #57
- Daniel Quevedo - Metis Tx
- Poster #33
- Ji-Hyun Park - Chungbuk National University
- Poster #99
- Javier Giménez Warren - Certest
- Poster #101
- Hyun-Bae Jie - Levatio Tx
- Poster #103
- Olivier Laczka - Noxopharm
- Poster #95
- Sunil Yadava - Georgia Tech
- Poster #91
- Federica Quattrone - Cutanos
Session 5:
Poster Session: Odd-numbered Posters
- 05:00 - 06:30 pm, CET
- Visit the Exhibiton/Poster Session area!
Conference Dinner & Session 6:
Keynote from Katalin Karikó
- 06:30 - 10:30 pm, CET
- 06:50 - 7:20 pm, CET
- Katalin Karikó - University of Pennsylvania / University of Szeged
- Developing mRNA for therapy
- Starting at 7:20 pm: Dinner only for participants in Berlin
Conference Day 2: Wednesday, November 1st, 2023 / 08:00 am - 07:00 pm, CET
- 05:30 - 07:00 pm, CET
Poster Session (even numbered) & Exhibition
Session 7:
Keynote from Philip Felgner
- 08:00 - 09:00 am, CET
- Chair: Daniel Siegwart
- Welcome & Logistics
- Alexander Zehnder - CureVac
- Philip Felgner - University of California
- 150 Years of Vaccine Science
Coffee Break
- 09:00 - 09:30 am, CET
Session 8:
Vaccines II
- 09:30 - 11:30 am, CET
- Chair: Norbert Pardi
- 09:30 am, CET
- Steve Roffler - Institute of Biomedical Sciences
- Anti-PEG antibodies: the good, the bad and the ugly
- 09:52 am, CET
- Jordan Minnell - Malaghan Institute of Medical Research
- mRNA vaccine against malaria tailored for liver-resident memory T cells
- 10:10 am, CET
- Benjamin Goldman-Israelow - Yale - VIRTUALLY
- Harnessing polymeric nanoparticles for respiratory mucosal mRNA vaccines
- 10:32 am, CET
- Igor Smolenov - Arcturus
- Self-amplifying RNA platform: Growing evidence from pivotal clinical studies
- 10:50 am, CET
- Colin Pouton - Monash Institute of Pharmaceutical Sciences
- mRNA COVID-19 vaccines encoding membrane-anchored spike protein RBDs induce strong immune responses and overcome immune imprinting
- 11:08 am, CET
- Janine Mühe - CureVac
- Immunogenicity and Protective activity of Messenger RNA Vaccine Candidates Against Yellow Fever Virus in Pre-clinical Animal Models
Lunch
- 11:30 am - 01:00 pm, CET
- Talks during the lunch break:
- 11:30 - 11:45 am, CET
- Romain Micol - Combined Therapeutics
- Revolutionizing the next generation of mRNA vaccines for improved biodistribution, safety and efficacy with the MOPCTX Platform
- 12:45 - 01:00 pm, CET
- Jing Zhu - ReciBioPharm
- Accelerating mRNA Clinical Development from Start to Finish
Session 9:
Delivery I
- 01:00 - 02:30 pm, CET
- Chair: Patrick Baumhof
- 01:00 pm, CET
- Gaurav Sahay - Oregon Health & Science University
- The quest for next generation lipid nanoparticles for cell-specific delivery of mRNA
- 01:18 pm, CET
- Qiaobing Xu - Tufts University
- Organ and cell selective delivery using synthetic biodegradable lipid nanoparticles for gene therapy and gene editing
- 01:36 pm, CET
- Ying Tam - Acuitas Therapeutics
- Characterizing the therapeutic application of messenger RNA-Lipid nanoparticles
- 01:54 pm, CET
- Marco Ciufolini - NanoVation Therapeutics.
- Development of Competent Ionizeable Lipids for the Delivery of Nucleic acids
- 02:12 pm, CET
- Kieu Lam - Genevant Sciences
- Optimizing Lipid Nanoparticles for Delivery in Primates
Coffee Break
- 02:30 - 03:00 pm, CET
Session 10:
Delivery II
- 03:00 - 4:30 pm, CET
- Chair: Daniel Siegwart
- 03:00 pm, CET
- Ilke Aernout - Ghent Research Group on Nanomedicines
- Exploring Galsomes, an mRNA based nanovaccine, for protection against intracellular bacterial infections
- 03:18 pm, CET
- Muthusamy Jayaraman - ReNAgade Therapeutics
- Novel LNP-Based Delivery of mRNA to Extra-Hepatic Tissues in NHPs
- 03:36 pm, CET
- Won Jong Kim - POSTECH
- Polymer nanoparticles for mRNA delivery
- 03:54 pm, CET
- Martin Rabel - PNI/Cytiva
- Fit-for-Purpose Lipid Nanoparticles to Accelerate Development of Genomic Medicines
- 04:12 pm, CET
- Dal-Hee Min - Seoul National University
- Next-generation drug delivery system, DegradaBALL, for advanced mRNA therapy and vaccines
Coffee Break
- 04:30 - 04:55 pm, CET
Session 11:
Introduction to the Alliance of mRNA Medicine
- 04:55 - 05:30 pm, CET
- Clay Alspach - Leavitt Partners
- Andreas Kuhn - BioNTech
- Morrie Ruffin - Adjuvant Partners
- Sara Singleton - Leavitt Partners
- Anshul Mangal - Project Farma
- Andrew Geall - Replicate Bioscience
Session 12:
Poster Session: Even-numbered Posters
- 05:30 - 07:00 pm, CET
- Visit the Exhibiton/Poster Session area!
Conference Day 3: Thursday, November 2nd, 2023 / 8:00 am - 4:00 pm, CET
Welcome & Logistics
- 08:00 - 08:10 am, CET
- Opening: Welcome & Logistics
- Alexander Zehnder - CureVac
Session 13:
Manufacturing
- 08:10 - 09:50 am, CET
- Chair: Patrick Baumhof
- Introduction of Session 13
- Patrick Baumhof - CureVac
- 08:10 am, CET
- Zoltán Kis - University of Sheffield
- Innovating and digitalising mRNA vaccine and therapeutics production processes
- 08:30 am, CET
- Venkata Indurthi - Aldevron
- Streamlined mRNA manufacturing: Innovative solutions to reduce timeline to clinic
- 08:46 am, CET
- Xiao Xiao - Synthgene Biotech
- Novel cap analogs and modified NTPs to enable therapeutic mRNA development
- 09:02 am, CET
- Scott Ripley - Cytiva/PNI
- Addressing GMP Manufacturing Challenges of mRNA-LNP Drug Products
- 09:18 am, CET
- Khaled Yamout - Trilink
- Analytical consideration to support successful mRNA programs
- 09:34 am, CET
- Andreas Wagner - Polymun - VIRTUALLY
- Guiding RNA formulations from laboratory research to the market – Lessons learned from development and optimization of LNP/liposome formulations
Awards
- 09:50 - 10:00 am, CET
- Poster prize winners will be announced
- Scientific Committee
Coffee Break
- 10:00 - 10:30 am, CET
Session 14:
Cancer Vaccines
- 10:30 am - 12:00 pm, CET
- Chair: Mathias Vormehr
- 10:30 am, CET
- Kyle Holen - ModeRNA
- A personalized cancer vaccine, mRNA-4157
- 10:46 am, CET
- Markus Zettl - CureVac
- Cancer mRNA vaccines ignite an effective anti-tumor immune response
- 11:02 am, CET
- Benjamin Rengstl - BioNTech
- BNT211: A Phase 1 Trial Evaluating Safety and Efficacy of CLDN6 CAR‐T Cells in combination with an CAR-T cell Amplifying RNA vaccine in Patients with CLDN6‐positive Advanced Solid Tumors
- 11:18 am, CET
- Jamile Ramos da Silva - Universidade de São Paulo
- Single immunizations of self-amplifying or non-replicating mRNA-LNP vaccines control HPV-associated tumors in mice
- 11:34 am, CET
- Wigard Kloosterman - CureVac
- Systematic identification of cancer neoantigens derived from neo-open reading frames
- 11:44 am, CET
- Vinod Balachandran - Memorial Sloan Kettering Cancer Center - VIRTUALLY
- Neoantigen quality predicts immunoediting in survivors of pancreatic cancer
Lunch
- 12:00 - 01:00 pm, CET
Session 15:
Therapeutics
- 01:00 - 02:30 pm, CET
- Chair: Tatiana Novobrantseva
- 01:00 pm, CET
- Jun Zhou - Tokyo Medical and Dental University (TMDU) - VIRTUALLY
- mRNA-Based Strategies for Osteoarthritis Treatment
- 01:10 pm, CET
- Ajit Magadum - Temple University, Philadelphia - VIRTUALLY
- Combinatorial Delivery of Serine Synthesis Pathway Genes Induced Cardiac Regeneration and Cardiac Function in Ischemic Heart Diseases
- 01:26 pm, CET
- Florian Leuschner - Universitaetsklinikum Heidelberg
- Prevention of heart failure after myocardial infarction: modulating inflammation with mRNA overexpression
- 01:42 pm, CET
- Zi Jun Emma Wang - Yoltech Therapeutics - VIRTUALLY
- Directed Evolution Strategies for Targeting Undruggable Targets in Gene Editing Therapies
- 01:58 pm, CET
- Hamideh Parhiz - Perelman School of Medicine / Univ Penn - VIRTUALLY
- RNA-based in vivo cellular reprogramming, an evolving gene therapy paradigm
- 14:14 pm, CET
- Andre Nel - UCLA - VIRTUALLY
- Liver-targeting Multi-epitope mRNA Tolerogenic Nanoparticles for the Treatment of Food allergy and Type I Diabetes
Break
- 02:30 - 02:45 pm, CET
Session 16:
Targeting
- 02:45 - 03:40 pm, CET
- Chair: Patrick Baumhof
- 02:45 pm, CET
- Dan Peer - Tel Aviv University
- Delivery of Therapeutic RNAs using Targeted Lipid Nanoparticles
- 03:10 pm, CET
- Magdalena M. Żak - Icahn School of Medicine at Mount Sinai
- A targeted systemic delivery platform of therapeutic modified mRNA and modRNA-derived antibodies for precision triple negative breast cancer treatment
- 03:25 pm, CET
- Cafer Ozdemir - Kernal Biologics
- Engineering Synthetic mRNAs That Are Selectively Translated In Cancer Cells
Passing of the baton and closing
- 03:40 - 04:00 pm, CET
- CureVac - ModeRNA
