Program 2022
Conference Day 1: Tuesday, November 8th, 2022 8:15 am - 08:00 pm, EST
For onsite participants:
- 5:00 - 6:30 pm, EST
Poster Session (Odd numbered) & Exhibition
- 6:30-8:00 pm, EST
Dinner + Keynote 1
Opening:
Welcome & Logistics
- 08:15 - 08:30 am, EST
- Opening: Welcome & Logistics
- Scientific commitee
Session 1:
An introduction to mRNA Medicines
- 08:30 - 10:00 am, EST
- Melissa Moore - Moderna
- mRNA Biology and Engineering
- Daniel Siegwart - UT Southwestern
- Formulation and Delivery
- Norbert Pardi - Univ Penn
- mRNA Vaccine Mechanisms
Coffee Break
- 10:00 - 10:30 am, EST
- Introduction of Session 2
- Norbert Pardi - Univ Penn
- Bali Pulendran - Standford Univ
- Systems vaccinology of COVID-19 mRNA vaccines
- Kelly Lindert - Arcturus
- Validation of Self-Amplified mRNA for COVID-19 in Phase III Efficacy Trials
- Robin Shattock - Imperial College, London
- Self-amplifying RNA: Applying clinical experience to platform improvements
- Wensheng Wei - Peking University - VIRTUALLY
- Circular RNA vaccines against SARS-CoV-2 and its emerging variants
- Emily Voigt - Acc to Adv Health Institute, Seattle
- Systems vaccinology of COVID-19 mRNA vaccines
- Dan Peer - Acc to Adv Health Institute, Seattle VIRTUALLY
- An Effective mRNA-LNP Vaccine Against a Highly Lethal Bacterium
Lunch Break
- 12:30 – 2:00 pm, EST
- Introduction of Session 3
- Andreas Kuhn - BioNTech
- Bijoyita Roy - NewEnglandBiolabs
- Systems vaccinology of COVID-19 mRNA vaccines
- Hiroshi Abe - Nagoya University
- Complete Chemical Synthesis of Minimal Messenger RNA by Efficient Chemical Capping Reaction
- Amy Walker - 4basebio
- Production of in vitro transcribed mRNA using synthetic, enzymatically produced linear DNA
- Bin Zhu - Huazhong U, Wuhan VIRTUALLY
- Psychrophilic phage VSW-3 RNA polymerase reduces both the terminal and the full-length dsRNA byproducts in in vitro transcription
- Evan Myers - TriLink
- Overcoming mRNA Process Optimization and Scalability Challenges
- Scott Ripley - Cytiva
- Nucleic Acid Therapeutics
Coffee Break
- 03:30 - 04:00 pm, EST
Session 4:
Flash Poster Talks / New Company Introductions
- 04:00 - 05:00 pm, EST
- Flash Poster Talks
- Maximiliano Cacicedo - Johannes-Gutenberg University, Germany
- Jian-dong Huang - University Hong Kong
- Sandro Roier - CureVac
- Di Zhang - UT Southwestern
- New Company Introductions
- Christian Cobaugh - Vernal Biosciences
- José Castillo - Quantoom Biosciences
- Kun Zhou - GeneLeap Biotech
Session 5:
Odd-numbered Posters
- 05:00 - 06:30 pm, EST
- Visit the Exhibiton/Postersession area!
Session 6:
Dinner + Keynote 1
- 06:30 - 08:00 pm, EST
- Peter Cullis - UBC
- Design of lipid nanoparticle delivery systems that enable nucleic acid-based drugs
Conference Day 2: Wednesday, November 9th, 2022 8:00 am - 7:00 pm, EST
Conference Day 2: Wednesday, November 9th, 2022 8:00 am - 7:00 pm, EST
Session 7: Keynote 2
- 08:00 - 09:00 am, EST
- Bob Langer - MIT
- From micro and nanotechnology delivery systems to mRNA therapies and what’s to come: How overcoming skepticism and barriers led to novel cancer treatments and vaccines, and new ways to tackle global health challenges
Coffee Break
- 09:00 - 09:30 am, EST
- Introduction of Session 8
- Melissa More - Moderna
- Julius Lucks - Northwestern University
- Dynamic RNA synthetic biology: Using discoveries from nascent RNA folding to drive RNA engineering
- Jody Puglisi - Stanford
- Dynamics of Translation
- Rachel Niederer - Yale/Univ Mich
- Uncovering novel translational control elements within 5'-UTRs
- Kristin Koutmou - Univ Mich
- Consequences of mRNA modifications on translation speed and fidelity
- Hani S. Zaher - Washington University
- N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products
- Melissa Van Dülmen - Washington University
- Photocaged 5′ cap analogues for optical control of mRNA translation in cells
- Jeff Coller - Johns Hopkins
- Development of a tethered mRNA Amplifier for the treatment of haploinsufficiency disorders
Lunch
- 11:30 am - 01:00 pm, EST
- Introduction of Session 9
- Dan Siegwart - UT Southwestern
- Jayesh Kulkarni - NanoVation
- Next-generation lipid nanoparticle technology for extrahepatic mRNA delivery
- Tim Leaver - Precision Nano
- Novel Ionizable Lipid Library for Enabling Non-Viral Delivery
- Thomas Madden - Acuitas Therapeutics
- Novel Ionizable Lipid Library for Enabling Non-Viral Delivery
- Hyukjin Lee - Ewha Womans University, South Korea
- Development and screening of ionizable lipid nanoparticles for vaccine and therapeutic applications
- Amy Rhoden Smith - Precision Biosciences
- Optimization strategies to achieve high efficiency gene editing in non-human primates using lipid nanoparticle delivery of mRNA
Coffee Break
- 02:30 - 03:00 pm, EST
Session 10:
Cancer Vaccines and Therapies
- 03:00 - 04:30 pm, EST
- Chair: Mustafa Diken
- Introduction of Session 10
- Mustafa Diken - BioNTech
- Lena Kranz - BioNTech
- RNA-encoded, extended half-life cytokines in combination with RNA vaccines for synergistic anti-tumor activity
- Steve Pascolo - University of Zurich
- Chemically synthesized minimal mRNA for anti-cancer vaccination
- James Byrne - U Iowa
- Using mRNA to protect cancer patients from radiation side effects
- Hayat Bähr-Mahmud - BioNTech
- BNT141: An LNP-formulated mRNA encoding an anti-Claudin18.2 RiboMab for the treatment of solid tumors
- Satoshi Uchida - Kyoto Prefecture Univ Med
- Hybridizing antigen mRNA with short double-stranded RNA adjuvants for safe and efficient cancer vaccines
Coffee Break
- 04:30 - 04:45 pm, EST
Session 11:
Flash Poster Talks and New Company Introductions
- 04:45 - 05:30 pm, EST
- Flash Poster Talks
- John Ramunas - Rejunvination Technologies
- Manfred Kraus - Kernal Biologics
- Beatriz Dias Barbieri -Univ Warwick, UK
- New Company Introductions
- Seyed Hossein - ReNAP Therapeutics
- Bas Evers - InProcess-LSP
- Juan Martinez - CerTest Vaccines
- Cafer Ozdemir - Kernal Biologics
- Justine McPartian - Tiba Biotech
Session 12:
Even-numbered Posters
- 05:30 - 07:00 pm, EST
- Visit the Exhibiton/Postersession area!
Conference Day 3: Thursday, November 10th, 2022 8:15 am - 4:45 pm, EST
Awards
- 08:15 - 08:30 am, EST
- Poster prize winners will be announced
- Scientific commitee
- Introduction of Session 13
- Patrick Baumhof - CureVac
- Ana Jaklenec - MIT - VIRTUALLY
- Microneedles for delivery of mRNA vaccines
- Emrah Ilker Ozay - SQZ Biotechnologies
- Co-delivery of 5 mRNAs to Human PBMCs Using the Cell Squeeze® Technology Generates Enhanced Antigen Presenting Cells (SQZ® eAPC) Augmenting Antigen-specific CD8+ T Cell Responses
- Giovanni Traverso - MIT/MGH
- Biomedical device development for gastrointestinal applications
- Gilles Di Vita - Divincell
- Polymeric Based Nanoparticle platform for tissue-specific delivery of functional mRNAs
- Anastasia Khvorova - UMass Med
- Transformative siRNA dianophores for extrahepatic delivery
Coffee Break
- 10:00 - 10:30 pm, EST
Session 14:
Regulatory Roundtable
- 10:30 - 12:00 pm, EST
- Lessons Learned from the COVID-19 Vaccine Experience Shaping Pandemic Preparedness and Future Regulatory Development for mRNA-based Vaccines and Therapeutics
- Industry Panel Members
- Constanze Blume - BioNTech
- Ruben Rizzi - BioNTech
- John Talian - CureVac
- Florian Neske - CureVac
- Charbel Haber - Moderna
- Speaker
- Peter Marks - Director of the Center for Biologics Evaluation and Research (CBER) at the Food and Drug Administration (FDA) - VIRTUALLY
- Marco Cavaleri - Head of Office Biological Health Threats and Vaccine Strategy, European Medicines Agency (EMA) - VIRTUALLY
- Adam Hacker - Head of Global Regulatory Affairs, Coalition for Epidemic Preparedness Innovations (CEPI) - VIRTUALLY
Lunch
- 12:00 am - 01:00 pm, EST
Session 15:
CMC and Quality Control
- 01:00 - 02:15 pm, EST
- Chair: Scott Nickerson
- Introduction of Session 15
- Scott Nickerson - Moderna
- Andreas Wagner - Polymun
- Guiding mRNA-LNP drug products from early R&D programs to the market
- Andreas Kuhn - BioNTech
- CMC development for mRNA-based therapeutics and vaccines
- Julian Mochayedi - MilliporeSigma
- Novel PCR-based mRNA drug substance manufacturing enhancing our integrated mRNA CDMO offering
- Tadas Trunca - Thermo Fisher
- Innovations to support the next generation of mRNA vaccines and therapeutics
- Roche TBA
Break
- 02:15 pm - 02:30 pm, EST
Session 16:
Therapeutics
- 02:30 - 04:30 pm, EST
- Chair: Patrick Baumhof
- Introduction of Session 16
- Patrick Baumhof - Curevac
- Joel Rurik - Univ Pennsylvania
- CAR T cells produced in vivo to treat cardiac injury
- Ajit Magadum - Temple Univ, Philadelphia
- Myocardial Delivery of PSAT1 Modified mRNA Induces Cardiac Regeneration and Function Post-Ischemic Cardiac Injury
- Elizabeth Rosado Balmayor - RWTH Aachen
- Efficient healing of large osseous segmental defects using optimized chemically modified messenger RNA encoding BMP-2
- David Lockhart - ReCode Therapeutics
- mRNA LNPs for the treatment of primary ciliary dyskinesia
- Marion Pönisch - CureVac
- mRNA therapies for liver fibrosis
- Paolo Martini - Moderna
- Messenger RNA therapy for the treatment of rare genetic disorders
- William Querbes - Tessera Therapeutics
- Harnessing mobile genetic elements to write DNA sequences with RNA
- Charles O’Donnell - Omega Therapeutics
- Pioneering a New Class of Precision Medicine: Design and Characterization of mRNA Therapeutics as Programmable Epigenetic Medicines
Passing of the baton and closing
- 04:30 - 4:45 pm, EST
