PROGRAM DAY 1: Monday, November 9th 2020

(All times shown as Eastern Standard Time, EST)

08:00 – 08:15 Welcome & Logistics Stephane Bancel and Melissa Moore
08:15 – 09:45 Session I: mRNA Biology and Translation Chair: Melissa Moore 
08:15 – 08:40 Single-cell transcriptome imaging and cell atlas of complex tissues Xiaowei Zhuang (HHMI/Harvard Chemistry)
08:40 – 09:05 Colliding ribosomes function as a gauge for activation of cellular stress responses Rachel Green (HHMI/Johns Hopkins Medical School)
09:05 – 09:30 Development of RNA structures for cancer immunotherapy

Kyuri Lee (Gyeongsang National University)

09:30 – 09:45 Decoding mRNA translatability and stability from the 5’UTR Shu-Bing Qian (Cornell University)
09:45 – 10:00 Break  
10:00 – 10:05 Keynote Introduction Stephane Bancel
10:05 – 10:30 Keynote Speaker
Please note: Taped talk – No Q&A
Anthony Fauci (NIAID/NIH) 
10:30 – 11:00 Break  
11:00 – 12:55 Session II: Delivery Chair: Dan Siegwart
11:00 – 11:20 mRNA Delivery Dan Anderson (MIT)
11:20 – 11:40 Biomaterials strategies to enhance and prolong the effects of therapeutic mRNA William L. Murphy (U.Wisconsin-Madison)
11:40 – 12:00 Supramolecular assemblies for enhanced mRNA delivery Horacio Cabral (U. Tokyo)
12:00 – 12:20 Boosting intracellular delivery of messenger RNA Gaurav Sahay (OHSU)
12:20 – 12:40 Advancing pulmonary delivery of mRNA therapeutics for the treatment of genetic diseases John Androsavich (Translate Bio)
12:40 – 12:55 COATSOME SS-Lipids as novel, biodegradable, ionizable Lipids for mRNA Therapeutics and Vaccines Syed Reza (NOF America)
12:55 – 13:10 Break  
13:10 – 14:40 Session III: Prophylactic and Therapeutic Vaccines Chair: Norbert Pardi
13:10 – 13:30 Development of broadly protective influenza virus vaccines using nucleoside-modified mRNA Norbert Pardi (UPenn)
13:30 – 13:50 A mRNA-LNP vaccine against Dengue Virus elicits robust, serotype-1 specific immunity Justin M Richner (University of Illinois)
13:50 – 14:10 Intranasal mRNA Vaccines:  COVID and far beyond Wim Tiest (Etherna)
14:10 – 14:25 Therapeutic vaccination of cancer patients with WT1 mRNA-electroporated dendritic cells:  Using mRNA as an active substance in the clinic since 2005 Zwi Berneman (Antwerp Univ Hospital)
14:25 – 14:40 Immunodominant Malaria Antigen, pfcsp Induces Functional, Protective Immune Responses in Mice using mRNA Platform Katherine Mallory (Walter Reed Army Institute of Research)
14:40 – 14:55 Developing an mRNA Vaccine Platform Across Multiple Infectious Disease Targets Danilo Casimiro (Sanofi)
Frank DeRosa (TranslateBio)
14:55 – 15:10 Break  
15:10 – 16:30 Session IV: Manufacturing, Analytics and Commercialization Chair: Patrick Baumhof
15:10 – 15:30 Meeting the quality and scale requirements for IVT enzymes in the production of therapeutic mRNAs John Pelletier (New England Biolabs)
15:30 – 15:50 Strategic CDMO partnering for accelerated mRNA vaccine development: A COVID-19 case study Anton McCaffrey (TriLink BioTechnologies)
15:50 – 16:10 Characterizing the therapeutic application of mRNA-lipid nanoparticles Thomas Madden (Acuitas)
16:10 – 16:30 Enabling mRNA Platform Commercialization and Setting Up for Future Success Tadas Trunca (Thermo Fisher)

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