• 05:00 - 6:30 pm, EST

Poster Session (Odd numbered) & Exhibition

• 06:30 - 8:00 pm, EST

Dinner + Keynote 1

Opening:
Welcome & Logistics

• 08:15 - 08:30 am, EST

• Opening: Welcome & Logistics
• Scientific Committee

Session 1:
An introduction to mRNA Medicines

• 08:30 - 10:00 am, EST

• This first session will consist of a series of teaching lectures to provide newcomers with the necessary background to understand current state-of-the-art and remaining challenges for making future mRNA medicines

• 08:30 am, EST
• Melissa Moore - Moderna
• mRNA Biology and Engineering

• 08:48 am, EST
• Daniel Siegwart - UT Southwestern
• Formulation and Delivery

• 09:06 am, EST
• Norbert Pardi - Univ Penn
• mRNA Vaccine Mechanisms

• 09:24 am, EST
• Scott Nickerson - Moderna
• GMP Manufacturing and Quality Control

• 09:42 am, EST
• Charbel Haber - Moderna
• Regulatory Process and Considerations

Coffee Break

• 10:00 - 10:30 am, EST

Session 2:
Advances in Prophylactic Vaccines

• 10:30 am - 12:30 pm, EST

• Chair: Norbert Pardi

• Introduction of Session 2
• Norbert Pardi - Univ Penn

• 10:30 am, EST
• Bali Pulendran - Standford Univ
• Systems vaccinology of COVID-19 mRNA vaccines

• 10:48 am, EST
• Kelly Lindert - Arcturus
• Validation of Self-Amplified mRNA for COVID-19 in Phase III Efficacy Trials

• 11:06 am, EST
• Robin Shattock - Imperial College, London
• Self-amplifying RNA: Applying clinical experience to platform improvements

• 11:24 am, EST
• Wensheng Wei - Peking University - VIRTUALLY
• Circular RNA vaccines against SARS-CoV-2 and its emerging variants

• 11:52 am, EST
• Emily Voigt - Acc to Adv Health Institute, Seattle
• An Intranasal saRNA Vaccine against SARS-CoV-2

• 11:52 am, EST
• Andrzej Dziembowski - Warsaw Univ
• In vivo re-adenylation of mRNA-1273 boost its efficacy

• 12:10 pm, EST
• Dan Peer - Tel Aviv Univ - VIRTUALLY
• An Effective mRNA-LNP Vaccine Against a Highly Lethal Bacterium

Lunch Break

• 12:30 – 02:00 pm, EST

Session 3: Advances in mRNA Synthesis

• 02:00 pm - 03:30 pm, EST

• Chair: Andreas Kuhn

• Introduction of Session 3
• Andreas Kuhn - BioNTech

• 02:00 pm, EST
• Bijoyita Roy - NewEnglandBiolabs
• N1-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs.

• 02:18 pm, EST
• Hiroshi Abe - Nagoya University
• Complete Chemical Synthesis of Minimal Messenger RNA by Efficient Chemical Capping Reaction

• 02:36 pm, EST
• Amy Walker - 4basebio
• Production of in vitro transcribed mRNA using synthetic, enzymatically produced linear DNA

• 02:46 pm, EST
• Bin Zhu - Huazhong U, Wuhan VIRTUALLY
• Psychrophilic phage VSW-3 RNA polymerase reduces both the terminal and the full-length dsRNA byproducts in in vitro transcription

• 02:56 pm, EST
• Evan Myers - TriLink
• Overcoming mRNA Process Optimization and Scalability Challenges

• 03:12 pm, EST
• Scott Ripley - Cytiva
• Making innovation reality: strategies for future manufacturing requirements

Coffee Break

• 03:30 - 04:00 pm, EST

Session 4:
Flash Poster Talks / New Company Introductions

• 04:00 - 05:00 pm, EST

• Chair: Melissa Moore

• Flash Poster Talks - 3 minutes for each talk

• Poster #5
• Maximiliano Cacicedo - Johannes-Gutenberg University, Germany

• Poster #11
• Jian-dong Huang - University Hong Kong

• Poster #14
• Ivan Corrêa - New England Biolabs

• Poster #51
• Sandro Roier - CureVac

• Poster #89
• Kristen Ott - Orna

• Poster #97
• Di Zhang - UT Southwestern

• New Company Introductions - 3 minutes for each talk

• Poster #25
• Christian Cobaugh - Vernal Biosciences

• Poster #99
• José Castillo - Quantoom Biosciences

• Poster #81
• Kun Zhou - GeneLeap Biotech

Session 5:
Odd-numbered Posters

• 05:00 - 06:30 pm, EST

• Visit the Exhibiton/Postersession area!

Session 6:
Dinner + Keynote 1

• 06:30 - 09:00 pm, EST

• Pieter Cullis - UBC
• Design of lipid nanoparticle delivery systems that enable nucleic acid-based drugs

Conference Day 2: Wednesday, November 9th, 2022 08:00 am - 07:00 pm, EST

• 05:30 - 07:00 pm, EST

Poster Session (even numbered) & Exhibition

Session 7: Keynote 2

• 08:00 - 09:00 am, EST

• Welcome & Logistics
• Melissa Moore - Moderna

• Bob Langer - MIT
• From micro and nanotechnology delivery systems to mRNA therapies and what’s to come: How overcoming skepticism and barriers led to novel cancer treatments and vaccines, and new ways to tackle global health challenges

Coffee Break

• 09:00 - 09:30 am, EST

Session 8:
mRNA Engineering and Translation

• 09:30 - 11:30 am, EST

• Chair: Melissa Moore

• 09:30 am, EST
• Julius Lucks - Northwestern University
• Dynamic RNA synthetic biology: Using discoveries from nascent RNA folding to drive RNA engineering

• 09:50 am, EST
• Jody Puglisi - Stanford
• Dynamics of Translation

• 10:10 am, EST
• Rachel Niederer - Yale/Univ Mich
• Uncovering novel translational control elements within 5'-UTRs

• 10:30 am, EST
• Kristin Koutmou - Univ Mich
• Consequences of mRNA modifications on translation speed and fidelity

• 10:50 am, EST
• Hani S. Zaher - Washington University
• N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products

• 11:10 am, EST
• Melissa Van Dülmen - University of Münster
• Photocaged 5′ cap analogues for optical control of mRNA translation in cells

• 11:20 am, EST
• Jeff Coller - Johns Hopkins
• Development of a tethered mRNA Amplifier for the treatment of haploinsufficiency disorders

Lunch

• 11:30 am - 01:00 pm, EST

Session 9:
LNP-mediated delivery

• 01:00 - 02:15 pm, EST

• Chair: Dan Siegwart

• Introduction of Session 9
• Dan Siegwart - UT Southwestern

• 01:00 pm, EST
• Jayesh Kulkarni - NanoVation
• Next-generation lipid nanoparticle technology for extrahepatic mRNA delivery

• 01:15 pm, EST
• Tim Leaver - Precision NanoSystems
• Novel Ionizable Lipid Library for Enabling Non-Viral Delivery

• 01:30 pm, EST
• Ying Tam - Acuitas Therapeutics
• Lipid Nanoparticles for Systemic Delivery of mRNA-based Therapeutics

• 01:45 pm, EST
• Hyukjin Lee - Ewha Womans University, South Korea
• Development and screening of ionizable lipid nanoparticles for vaccine and therapeutic applications

• 02:00 pm, EST
• Amy Rhoden Smith - Precision Biosciences
• Optimization strategies to achieve high efficiency gene editing in non-human primates using lipid nanoparticle delivery of mRNA

Coffee Break

• 02:15 - 02:45 pm, EST

Session 10:
Cancer Vaccines and Therapies

• 02:45 - 4:15 pm, EST

• Chair: Mustafa Diken

• Introduction of Session 10
• Mustafa Diken - BioNTech

• 02:45 pm, EST
• Lena Kranz - BioNTech
• RNA-encoded, extended half-life cytokines in combination with RNA vaccines for synergistic anti-tumor activity

• 03:00 pm, EST
• Steve Pascolo - University of Zurich
• Chemically synthesized minimal mRNA for anti-cancer vaccination

• 03:15 pm, EST
• James Byrne - U Iowa
• Using mRNA to protect cancer patients from radiation side effects

• 03:30 pm, EST
• Hayat Bähr-Mahmud - BioNTech
• BNT141: An LNP-formulated mRNA encoding an anti-Claudin18.2 RiboMab for the treatment of solid tumors

• 03:45 pm, EST
• Satoshi Uchida - Kyoto Prefecture Univ Med
• Hybridizing antigen mRNA with short double-stranded RNA adjuvants for safe and efficient cancer vaccines

• 03:55 pm, EST
• Elizabeth Rosado Balmayor - RWTH Aachen
• Efficient healing of large osseous segmental defects using optimized chemically modified messenger RNA encoding BMP-2

Coffee Break

• 04:15 - 04:45 pm, EST

Session 11:
Flash Poster Talks and New Company Introductions

• 04:45 - 05:33 pm, EST

• Chair: Patrick Baumhof

• Flash Poster Talks

• Poster #8
• Katie McCormick - Royal College of Surgeons, Dublin

• Poster #20
• John Ramunas - Rejunvination Technologies

• Poster #40
• Manfred Kraus - Kernal Biologics

• Poster #104
• Beatriz Dias Barbieri - Imperial College London, UK

• Poster #30
• Sean Dilliard - UTSouthwestern

• New Company Introductions

• Poster #4
• Seyed Hossein - ReNAP Therapeutics

• Poster #10
• Bas Evers - InProcess-LSP

• Poster #64
• Juan Martinez - CerTest Vaccines

• Poster #92
• Cafer Ozdemir - Kernal Biologics

• Poster #106
• Justine McPartlan - Tiba Biotech

• Poster #101
• Eric Jan - Univ British Columbia

Session 12:
Even-numbered Posters

• 05:30 - 07:00 pm, EST

• Visit the Exhibiton/Postersession area!

Welcome & Logistics

• 08:20 - 08:30 am, EST

• Opening: Welcome & Logistics
• Melissa Moore - Moderna

Session 13:
Alternative Delivery Mechanisms

• 08:30 - 09:50 am, EST

• Chair: Patrick Baumhof

• Introduction of Session 13
• Patrick Baumhof - CureVac

• 08:30 am, EST
• Ana Jaklenec - MIT
• Microneedles for delivery of mRNA vaccines

• 08:50 am, EST
• Emrah Ilker Ozay - SQZ Biotechnologies
• Co-delivery of 5 mRNAs to Human PBMCs Using the Cell Squeeze® Technology Generates Enhanced Antigen Presenting Cells (SQZ® eAPC) Augmenting Antigen-specific CD8+ T Cell Responses

• 09:00 am, EST
• Giovanni Traverso - MIT/MGH
• Biomedical device development for gastrointestinal applications

• 09:20 am, EST
• Gilles Di Vita - Divincell
• Polymeric Based Nanoparticle platform for tissue-specific delivery of functional mRNAs

• 09:30 am, EST
• Anastasia Khvorova - UMass Med
• Transformative siRNA dianophores for extrahepatic delivery

Awards

• 09:50 - 10:00 am, EST

• Poster prize winners will be announced
• Scientific Committee

Coffee Break

• 10:00 - 10:30 am, EST

Session 14:
Regulatory Roundtable

• 10:30 am - 12:00 pm, EST

• Chair: Charbel Haber

• Lessons Learned from the COVID-19 Vaccine Experience Shaping Pandemic Preparedness and Future Regulatory Development for mRNA-based Vaccines and Therapeutics

• 10:30 am, EST
• Charbel Haber - Moderna
• Constanze Blume - BioNTech
• Regulatory perspectives obtained from COVID-19 vaccine development

• 10:40 am, EST
• Adam Hacker - CEPI - VIRTUALLY
• Future Pandemic Preparedness

• 10:50 am, EST
• Q&A

• 11:00 am, EST
• Charbel Haber - Moderna
• Constanze Blume - BioNTech
• Ruben Rizzi - BioNTech
• John Talian - CureVac
• Florian Neske - CureVac - VIRTUALLY
• Adam Hacker - CEPI - VIRTUALLY
• Marco Cavaleri - EMA - VIRTUALLY
• Peter Marks - FDA - VIRTUALLY

Lunch

• 12:00 am - 01:00 pm, EST

Session 15:
CMC and Quality Control

• 01:00 - 02:15 pm, EST

• Chair: Scott Ripley

• Introduction of Session 15
• Scott Ripley - Cytiva

• 01:00 pm, EST
• Andreas Wagner - Polymun
• Guiding mRNA-LNP drug products from early R&D programs to the market

• 01:15 pm, EST
• Andreas Kuhn - BioNTech
• Reduction of double-stranded RNA in in vitro transcribed mRNA

• 01:30 pm, EST
• Julian Mochayedi - MilliporeSigma
• Novel PCR-based mRNA drug substance manufacturing enhancing our integrated mRNA CDMO offering

• 01:45 pm, EST
• Tadas Trunca - Thermo Fisher
• End to end solutions for mRNA therapeutics and vaccines

• 02:00 pm, EST
• Elaine Peters - Roche Genentech
• Defining Scale-Up Challenges

Break

• 02:15 - 02:30 pm, EST

Session 16:
Therapeutics

• 02:30 - 04:00 pm, EST

• Chair: Patrick Baumhof

• Introduction of Session 16
• Patrick Baumhof - CureVac

• 02:30 pm, EST
• Joel Rurik - Univ Pennsylvania
• CAR T cells produced in vivo to treat cardiac injury

• 02:45 pm, EST
• Ajit Magadum - Temple Univ, Philadelphia
• Myocardial Delivery of PSAT1 Modified mRNA Induces Cardiac Regeneration and Function Post-Ischemic Cardiac Injury

• 02:55 pm, EST
• David Lockhart - ReCode Therapeutics
• SORT LNP-formulated mRNA for the treatment of primary ciliary dyskinesia

• 03:10 pm, EST
• Marion Pönisch - CureVac
• Transcription factor mRNA therapy: a potent tool in liver disease

• 03:25 pm, EST
• Paolo Martini - Moderna
• Messenger RNA therapy for the treatment of rare genetic disorders

• 03:40 pm, EST
• William Querbes - Tessera Therapeutics
• Harnessing mobile genetic elements to write DNA sequences with RNA

• 03:50 pm, EST
• Charles O’Donnell - Omega Therapeutics
• Pioneering a New Class of Precision Medicine: Design and Characterization of mRNA Therapeutics as Programmable Epigenetic Medicines

Passing of the baton and closing

• 04:00 - 4:15 pm, EST